The science behind GloNua
Our Mission
At GloNua, we aim to deliver complete dietary solutions in nutritional supplements for individuals focused on self improvement. We are focused on specific functional food components that scientifically enhance and help the body function better in a more natural way.
The Science behind our products has grown now for many years. The key benefits of Exogenous Ketones BhB, MCT Oil Powder & Collagen Protein Powders for body condition (fat loss), better cognition and recovery performance are all without question.
I and numerous others including many athletes and the general public have used GloNua now with amazing results. Key up to date research has now found that the use of exogenous ketones or MCT are both safe and a very effective method in aiding and enhancing the process of keto-adaption without the extreme difficulty of sticking to a strict ketogenic diet. This is particularly true for those who prefer or need a cyclic approach to the ketogenic lifestyle.
Weight loss, improved physical performance
Better cognitive function
Better eating behavior and metabolic profile in a 12-week ketogenic diet
MCT Oil Powder:
Did you know that consuming medium chain triglyceride oil can induce a mild state of nutritional ketosis without the need to reduce dietary carbohydrate?Have you ever wondered why?
Medium-chain triglycerides (MCTs) are a type of dietary fat that differ from other fats such as short- or long-chain triglycerides in terms of their structure and metabolism. When consumed, MCTs undergo a unique process in the body, which ultimately leads to the production of ketones.
Due to their length, MCTs are rapidly absorbed in the small intestine and transported directly to the liver via the portal vein. Once in the liver, MCTs are broken down through a process called beta-oxidation. Enzymes in the liver convert MCTs into medium-chain fatty acids (MCFA), primarily in the form of octanoic acid (C8) and decanoic acid (C10).
The next step of their metabolism involves the conversion of MCFA into ketones. This process occurs in the liver's mitochondria, where MCFA undergo beta-oxidation, producing acetyl-CoA molecules. Unlike long-chain fatty acids, which require a carnitine shuttle to enter the mitochondria, MCFA can freely cross the mitochondrial membrane.
Once inside, the rapid influx of MCFA-derived acetyl-CoA molecules overwhelm the flow of metabolites able to combine with oxaloacetate and enter the Kreb’s Cycle, causing the excess to be shunted towards the ketogenesis pathways. This results in the production of the ketone bodies beta-hydroxybutyrate (BHB) and acetoacetate (AcAc) which are shipped from the liver and circulate in the bloodstream, where they are taken up by extrahepatic tissues. Notably, the brain is a particularly avid ketone-user that will rapidly and efficiently take up and metabolize ketones at a rate relative to their concentration in the blood.
Because of these unique properties of MCTs, scientists believe that their supplementation may provide therapeutic benefits of ketosis in a variety health conditions, especially those characterized by impaired glucose metabolism, such as mild cognitive impairment or Alzheimer’s disease.
Ref: MetabolicHealthSummit
Exogenous Ketone Bodies:
Ketones are a fuel for our energy production factory within the each cell in our body called mitochondria. Ketones are non-reliant on Sugar or Glycogen to generate ATP to fuel our CNS Muscle, Organs and particularly the Brain.
Humans make three types of ketone. These are often referred to as ‘ketone bodies’ or ‘ketones’
Acetone , Acetoaceate ( also know as Acetoacetic Acid), Beta-Hydroxybutyric Acid (also known as Beta Hydroxybuyrate or BHB).
Exogenous ketones are ketones that are ingested through a nutritional supplement. Current examples of these are Ketone Salts and Ketone Esters. Ketones made in the liver are more properly referred to as endogenous ketones.
Exogenous = Originates from a source external from the body.
Endogenous = Originates from inside the body.
Why use Exogenous Ketones?
Exogenous ketone supplements may provide many benefits.
https://ketonutrition.org/benefits-of-ketones/
These include athletic performance enhancement, greater weight loss, cancer prevention, cognitive improvement and anti-inflammatory properties.
Supplementing with exogenous ketones allows you to experience ketosis - the benefits of elevated blood ketone levels, without having to follow such a restrictive ketogenic diet, or super low carb diet, which is often difficult for some people to adhere to. Optimize your human potential.
Did you know that the ketone body acetoacetate produced from fat metabolism may protect against one of the harmful effects of excess sugar?
One of the harmful effects of excess sugar is its ability to attach to proteins and alter their shape and function. This process is called glycation, and can result in the formation of advanced glycation end products (AGEs). AGEs are associated with advanced aging and are found at high levels in many chronic diseases. They are especially concerning for diabetics who run the risk of hyperglycemia and glucose mismanagement. In fact, AGEs have been shown to contribute to various diabetic complications.
The ketone body acetoacetate has been shown to bind to and scavenge a reactive intermediate of sugar metabolism called methylglyoxal that is known to contribute to the formation of AGEs. Thus, this discovery highlights a new role of ketones, one with the potential to protect against a toxic effect of excess sugar metabolism. Preventing high blood sugar levels is one way to minimize the risk of AGE formation, and considering this recent discovery, researchers are wondering if ketones themselves may add another layer of protection!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902005/
Quality
We have the highest quality ingredients and packaging materials to ensure the best possible product.
All our Ingredients come from fully certified and quality assured (both NSF & Informed Choice) production facilities.
We go further to ensure the best manufacturing process and certifications, whilst at the same time, not making false claims unless they have been proven by scientific research and publications. This ensures the provision of excellence to our customers.
Document Controls.
Personnel & Facility checks. ( ISO Certified).
Sanitation Procedures.
100% Traceability.
Certified Laboratory Testing.
THE SCIENCE BEHIND THE LIFESTYLE
Click on the links below for more interesting reading.
β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications
https://www.cell.com/heliyon/fulltext/S2405-8440(23)08306-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844023083068%3Fshowall%3Dtrue
Levels of most cardiometabolic outcomes decreased linearly with the decrease in carbohydrate intake.
https://pubmed.ncbi.nlm.nih.gov/35537861/
https://www.mdpi.com/1422-0067/23/23/14564
Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases:
https://www.mdpi.com/2072-6643/13/7/2197/htm
https://pubmed.ncbi.nlm.nih.gov/33637354/
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP281988
Ohio State University 2018 Keto Conferance. Emerging Science of Nutritional Ketosis.
https://www.physiology.org/doi/abs/10.1152/ajpendo.1992.262.5.e631
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436967/
β-Hydroxybutyrate: A signaling metabolite in starvation response?Rojas-Morales P, Tapia E, Pedraza-Chaverri J.Cell Signal. 2016 Aug;28(8):917-23. doi: 10.1016/j.cellsig.2016.04.005. Epub 2016 Apr 13.PMID: 27083590
From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience https://link.springer.com/article/10.1007/s11357-020-00277-y
https://www.nih.gov/news-events/nih-research-matters/brown-fat-associated-less-heart-metabolic-disease
Review.
Body composition changes in physically active individuals consuming ketogenic diets https://jissn.biomedcentral.com/articles/10.1186/s12970-021-00440-6
Ketone bodies as signaling metabolites.Newman JC, Verdin E.Trends Endocrinol Metab. 2014 Jan;25(1):42-52. doi: 10.1016/j.tem.2013.09.002. Epub 2013 Oct 18.PMID: 24140022 Free PMC article.
Review.
β-hydroxybutyrate: much more than a metabolite.Newman JC, Verdin E.Diabetes Res Clin Pract. 2014 Nov;106(2):173-81. doi: 10.1016/j.diabres.2014.08.009. Epub 2014 Aug 19.PMID: 25193333 Free PMC article. Review.
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD.Nat Med. 2015 Mar;21(3):263-9. doi: 10.1038/nm.3804. Epub 2015 Feb 16.PMID: 25686106 Free PMC article.
The Ketone Body, β-Hydroxybutyrate Stimulates the Autophagic Flux and Prevents Neuronal Death Induced by Glucose Deprivation in Cortical Cultured Neurons.Camberos-Luna L, Gerónimo-Olvera C, Montiel T, Rincon-Heredia R, Massieu L.Neurochem Res. 2016 Mar;41(3):600-9. doi: 10.1007/s11064-015-1700-4. Epub 2015 Aug 25.PMID: 26303508
Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases.Jensen NJ, Wodschow HZ, Nilsson M, Rungby J.Int J Mol Sci. 2020 Nov 20;21(22):8767. doi: 10.3390/ijms21228767.PMID: 33233502 Free PMC article. Review.
Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases.Asif S, Morrow NM, Mulvihill EE, Kim KH.Front Genet. 2020 Oct 15;11:590369. doi: 10.3389/fgene.2020.590369. eCollection 2020.PMID: 33193730 Free PMC article.
Review.
Beta-Hydroxybutyrate Enhances BDNF Expression by Increasing H3K4me3 and Decreasing H2AK119ub in Hippocampal Neurons.Hu E, Du H, Shang S, Zhang Y, Lu X.Front Neurosci. 2020 Oct 28;14:591177. doi: 10.3389/fnins.2020.591177. eCollection 2020.PMID: 33192276 Free PMC article.
Epigallocatechin Gallate Effectively Affects Senescence and Anti-SASP via SIRT3 in 3T3-L1 Preadipocytes in Comparison with Other Bioactive Substances.Lilja S, Oldenburg J, Pointner A, Dewald L, Lerch M, Hippe B, Switzeny O, Haslberger A.Oxid Med Cell Longev. 2020 Oct 21;2020:4793125. doi: 10.1155/2020/4793125. eCollection 2020.PMID: 33149809 Free PMC article.
https://ketonutrition.org/ketones-and-nafld/
Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes
https://eje.bioscientifica.com/view/journals/eje/aop/eje-19-0710/eje-19-0710.xml
Cahill, G.F., Jr. (1970). Starvation in man. New Engl J Med 282, 668-675.
Ohio State University 2018 Keto Conferance. Emerging Science of Nutritional Ketosis.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC507673/
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30611-4
https://ncbi.nlm.nih.gov/pubmed/31820376
https://ncbi.nlm.nih.gov/pubmed/28398950
https://sciencedirect.com/science/article/pii/S1550413116304387
https://ncbi.nlm.nih.gov/pubmed/28588499
https://frontiersin.org/articles/10.3389/fphys.2017.00806/full…
https://ncbi.nlm.nih.gov/pubmed/28599043
https://ncbi.nlm.nih.gov/pubmed/31730565
ENHANCE YOUR METABOLIC SYSTEM TODAY
A reduced carbohydrate diet is a better approach for numerous health outcomes and leads to an enhanced you. By adding Goketo BhB or MCT you can really feel the difference in your everyday life, cognition, recreation / workouts. GloNua ranges are formulated with 100% pure BhB Ketones and MCT C8 coconut powder given you a superior dietary supplement advantage.