The science behind GloNua

Our Mission

as a health & wellness brand Glonua, We strive to develop, learn, share and help people realize overall better health. I am truly passionate and endeavour to empower people to achieve a healthy weight, prevent chronic diseases by providing advise and support to all who seek better health both in body & mind.

Diet and exercise are fundamental components of our well-being and vitality.

Incorporating regular exercise is crucial for maintaining overall well-being. Physical activity helps control weight, boosts cardiovascular health, and improves mental health by releasing mood-lifting endorphins. Whether it's a gym workout, yoga, or a daily walk, consistency is key to staying fit and reducing stress.

Reconnecting with nature offers profound benefits for both body and mind. Spending time outdoors can lower stress, improve mood, and enhance overall wellness. Activities like hiking, beach walks, or park visits promote physical fitness and provide a refreshing break from the modern, sedentary lifestyle, making nature an essential part of holistic health.

Diet and exercise are essential components that lay the groundwork for our being. Here at GloNua, we acknowledge their crucial importance in attaining peak health and overall wellness. Our brand is dedicated to offering advice and consultancy supported by scientific research that complement a well-rounded diet and consistent exercise and supplements enabling people to progress on their path to complete well-being.

Embrace the impact of nutrition, physical activity, and mindfulness alongside GloNua, and pave the way to realizing your utmost capabilities in body and mind.

It's what's inside
that counts.

Adopting a nutrient dense diet based on thousands of years of evolution and genetic modelling can significantly enhance your health. By focusing on whole, less processed foods like Meats, vegetables, healthy fats and other proteins ignite your metabolic system increase overall health and reduce the risk of chronic diseases. This approach promotes sustained energy, better digestion, better mood and cognition, mental energy and positive mindset with a healthier body & mind.

THE SCIENCE BEHIND THE LIFESTYLE

Click on the links below for more interesting reading.

β-Hydroxybutyrate as an epigenetic modifier: Underlying mechanisms and implications

https://www.cell.com/heliyon/fulltext/S2405-8440(23)08306-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405844023083068%3Fshowall%3Dtrue

Levels of most cardiometabolic outcomes decreased linearly with the decrease in carbohydrate intake.

https://pubmed.ncbi.nlm.nih.gov/35537861/

https://www.mdpi.com/1422-0067/23/23/14564

Beneficial Effects of Exogenous Ketogenic Supplements on Aging Processes and Age-Related Neurodegenerative Diseases:

https://www.mdpi.com/2072-6643/13/7/2197/htm

https://pubmed.ncbi.nlm.nih.gov/33637354/

ketone monoester supplementation improves cerebral blood flow and cognition in obesity: A randomized cross-over trial

https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP281988

The Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease

Weight loss, improved physical performance, cognitive function, eating behavior, and metabolic profile in a 12-week ketogenic diet in obese adults

Ohio State University 2018 Keto Conferance. Emerging Science of Nutritional Ketosis. 

Stubbs, B.Cox, P.; Evans, R.; Santer, P.; Miller, J.; Faull, O.; Magor-Elliott, S.; Hiyama, S.; Stirling, M.; Clarke, K. (2017). On the metabolism of exogenous ketones in humans. Front. Physiol.

Cox, P.J., Kirk, T., Ashmore, T., Willerton, K., Evans, R., Smith, A., Murray, Andrew J., Stubbs, B., West, J., McLure, Stewart W., et al. (2016). Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes. Cell Metabolism 24, 1-13.

https://www.physiology.org/doi/abs/10.1152/ajpendo.1992.262.5.e631

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7436967/

β-Hydroxybutyrate: A signaling metabolite in starvation response?Rojas-Morales P, Tapia E, Pedraza-Chaverri J.Cell Signal. 2016 Aug;28(8):917-23. doi: 10.1016/j.cellsig.2016.04.005. Epub 2016 Apr 13.PMID: 27083590

From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience https://link.springer.com/article/10.1007/s11357-020-00277-y

https://www.nih.gov/news-events/nih-research-matters/brown-fat-associated-less-heart-metabolic-disease

Review.

Body composition changes in physically active individuals consuming ketogenic diets https://jissn.biomedcentral.com/articles/10.1186/s12970-021-00440-6

Ketone bodies as signaling metabolites.Newman JC, Verdin E.Trends Endocrinol Metab. 2014 Jan;25(1):42-52. doi: 10.1016/j.tem.2013.09.002. Epub 2013 Oct 18.PMID: 24140022 Free PMC article.

Review.

β-hydroxybutyrate: much more than a metabolite.Newman JC, Verdin E.Diabetes Res Clin Pract. 2014 Nov;106(2):173-81. doi: 10.1016/j.diabres.2014.08.009. Epub 2014 Aug 19.PMID: 25193333 Free PMC article. Review.

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease.Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD.Nat Med. 2015 Mar;21(3):263-9. doi: 10.1038/nm.3804. Epub 2015 Feb 16.PMID: 25686106 Free PMC article.

The Ketone Body, β-Hydroxybutyrate Stimulates the Autophagic Flux and Prevents Neuronal Death Induced by Glucose Deprivation in Cortical Cultured Neurons.Camberos-Luna L, Gerónimo-Olvera C, Montiel T, Rincon-Heredia R, Massieu L.Neurochem Res. 2016 Mar;41(3):600-9. doi: 10.1007/s11064-015-1700-4. Epub 2015 Aug 25.PMID: 26303508

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases.Jensen NJ, Wodschow HZ, Nilsson M, Rungby J.Int J Mol Sci. 2020 Nov 20;21(22):8767. doi: 10.3390/ijms21228767.PMID: 33233502 Free PMC article. Review.

Understanding Dietary Intervention-Mediated Epigenetic Modifications in Metabolic Diseases.Asif S, Morrow NM, Mulvihill EE, Kim KH.Front Genet. 2020 Oct 15;11:590369. doi: 10.3389/fgene.2020.590369. eCollection 2020.PMID: 33193730 Free PMC article.

Review.

Beta-Hydroxybutyrate Enhances BDNF Expression by Increasing H3K4me3 and Decreasing H2AK119ub in Hippocampal Neurons.Hu E, Du H, Shang S, Zhang Y, Lu X.Front Neurosci. 2020 Oct 28;14:591177. doi: 10.3389/fnins.2020.591177. eCollection 2020.PMID: 33192276 Free PMC article.

Epigallocatechin Gallate Effectively Affects Senescence and Anti-SASP via SIRT3 in 3T3-L1 Preadipocytes in Comparison with Other Bioactive Substances.Lilja S, Oldenburg J, Pointner A, Dewald L, Lerch M, Hippe B, Switzeny O, Haslberger A.Oxid Med Cell Longev. 2020 Oct 21;2020:4793125. doi: 10.1155/2020/4793125. eCollection 2020.PMID: 33149809 Free PMC article.

https://ketonutrition.org/ketones-and-nafld/

Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes

https://eje.bioscientifica.com/view/journals/eje/aop/eje-19-0710/eje-19-0710.xml

Veech RL, Bradshaw PC, Clarke K, Curtis W, Pawlosky R, King MT. Ketone bodies mimic the life span extending properties of caloric restriction. IUBMB Life. 2017;69(5):305-314

Holdsworth, D.A., Cox, P.J., Kirk, T., Stradling, H., Impey, S.G., and Clarke, K. (2017). A Ketone Ester Drink Increases Postexercise Muscle Glycogen Synthesis in Humans. Med Sci Sports Exerc.

Vandoorne, T., De Smet, S., Ramaekers, M., Van Thienen, R., De Bock, K., Clarke, K., and Hespel, P. (2017). Intake of a Ketone Ester Drink during Recovery from Exercise Promotes mTORC1 Signaling but Not Glycogen Resynthesis in Human Muscle. Front. Physiol. 8, 310.

Sato, K., Kashiw.aya, Y., Keon, C.A., Tsuchiya, N., King, M.T., Radda, G.K., Chance, B., Clarke, K., and Veech, RL. (1995). Insulin, ketone bodies, and mitochondrial energy transduction. FASEB J. 9, 651-658.

Cahill, G.F., Jr. (1970). Starvation in man. New Engl J Med 282, 668-675.

Ohio State University 2018 Keto Conferance. Emerging Science of Nutritional Ketosis. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC507673/

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(19)30611-4

https://ncbi.nlm.nih.gov/pubmed/31820376

https://ncbi.nlm.nih.gov/pubmed/28398950

https://sciencedirect.com/science/article/pii/S1550413116304387

https://ncbi.nlm.nih.gov/pubmed/28588499

https://frontiersin.org/articles/10.3389/fphys.2017.00806/full…

https://ncbi.nlm.nih.gov/pubmed/28599043

https://ncbi.nlm.nih.gov/pubmed/31730565

ENHANCE YOUR METABOLIC SYSTEM TODAY

A reduced carbohydrate diet is a better approach for numerous health outcomes and leads to an enhanced you. By adding Goketo  BhB or MCT you can really feel the difference in your everyday life, cognition, recreation / workouts. GloNua ranges are formulated with 100% pure BhB Ketones and MCT C8 coconut powder given you a superior dietary supplement advantage.